It's just not the best matchup on the schedule. No. The Tigers are more vulnerable to an upset than their Top Five ranking would seem. Dimers has free College Football picks, College Football predictions today and College Football computer picks for every game of the NCAA Football regular season and postseason. Not only was Rutgers held to 17 points or fewer for a third consecutive game against an FBS opponent, but a defense that had held its first four opponents below 280 total yards was torn to pieces. There were nine losses by AP Top 25 teams in Week 5 as the Tilt-A-Whirl known as the 2021 college football season kicked into an even higher gear for the start of October. The Wolverines are looking to get back in the CFP after a mortifying appearance in 2021 against Georgia. Unless otherwise noted, games are assumed to take place on Saturday. 11 Utah for prediction. South Florida, meanwhile, is having a rough season so far. The pro football world is descending on Indianapolis for the annual NFL Scouting Combine this week, where 2023 draft prospects will be put through a gauntlet of on-field workouts, off-field medical exams, media . ET, ESPN3), No. Clemson's offense, with a much more comfortable looking DJ Uiagalelei under center, should roll on Saturday night. It's unclear if either QB will suit up Saturday. Multiple teams from the conference are in the running for the top four after the initial CFP rankings release, as are usual challengers Ohio State, Clemson and Michigan. 117: Central Michigan Chippewas 30.2. ET: Virginia Tech 17, Georgia Tech 14, South Florida at Temple, 2 p.m. Miami first-year head coach Mario Cristobal knows how important a game like this would be to get the Hurricanes back on track. Oregon has rattled off three straight wins over BYU, Washington State and Stanford. 10 Florida, No. The Horned Frogs handed Oklahoma its second straight loss last week, winning 55-24 in a game that wasn't all that close from the start. I think UNC has too much firepower on offense for this Canes defense. ET: UConn-Vanderbilt was on ESPNU this past weekend, and it actually ended up producing one of the most entertaining fourth quarters of the day, ending on a game-winning field goal for the Commodores at the buzzer. There are three matchups this weekend pitting top 25 ranked teams on . The Boilermakers lost two of their first three games of the season against Penn State and Syracuse, but the win over Minnesota brought them to 3-2. Pitt was a 21.5-point favorite, so it was a huge win for Key and a struggling Tech team that's 2-3 on the season. It is allowing just 8.9 points and 75.6 yards on the ground. Here are our picks straight up and against the spread for Week 6 . This should also give the ACC's rushing leader, running back Sean Tucker, time to rest uphe got banged up during Syracuse's blowout win over Wagner. Still, a fight for the top four will get even tougher in the next few weeks. And in each of the past two seasons, he racked up more rushing yards against Virginia than he did against any other foe. I like Oklahoma State at home here. Top college football predictions for Week 6. ET: TCU's defense has allowed at least 32 points and more than 400 yards of total offense in three consecutive games against Cal, SMU and Texas. The 2021 college football season is underway. Central Michigan at Northern Illinois, 7 p.m. We will have 6 more Premium Picks against the spread this week! If Key keeps winning, he could win the permanent head coaching job. Arkansas had high hopes heading into the season behind an established quarterback in KJ Jefferson, but a three-game losing streak in late September and early October had the Razorbacks' heads down. Unfortunately the Buckeyes will hand Sparty its fourth-straight loss of the season on Saturday. Michigan has impressed the last two weeks, defeating Maryland and beating Iowa on the road handily 27-14. But Arkansas had two long passing touchdowns en route to 448 total yards in Week 4 and Mississippi State threw for more than 400 yards this past weekend. ET: Marshall 28, Old Dominion 17, Baylor at Oklahoma, 3 p.m. 1 team in the country at home next week, but a road win in Baton Rouge is more important this weekend. Kansas State looks like one of the best teams in the Big 12, having upset Oklahoma 41-34 and beating Texas Tech 37-28 in back-to-back weeks. 15 Wake Forest (-15) (7:30 p.m. Penn State hasn't beaten OSU since 2017, and Michigan defeated the Nittany Lions 21-17 last season. Top Week 6 college football predictions. The saving grace for LSU is that Kentucky doesn't have a ball-hawking defense (three turnovers forced through five games) and the Wildcats haven't been particularly potent on offense as of late either. If Sanders is able to suit up against Kansas, the Cowboys will leave town with a victory, but it's a toss-up if Daniels is back in the lineup. ND beat Cal 24-17 at home, and went on the road to beat an undefeated UNC team 45-32. Truly, it wouldn't be a surprise if Coastal Carolina scores on every possession. Prediction:Michigan State 31, Rutgers 20, No. No. Still, Cincinnati is a quality 4-1 team that beat a Power 5 squad in Indiana in Week 4. Tennessee having the week off between the Florida and LSU games should help with its preparation, and it should handle the Tigers if its offense flexes its muscle, as it has in the first four games. No. Two disappointing teams will face off in College Station for what was projected to be an important game in SEC title picture prior to the start of the season. The Demon Deacons are coming off of a 31-21 road win over a much improved Florida State team. (Arkansas is ranked higher, but Ole Miss is the favorite, so yes, it'd be an upset.). Jay Biggerstaff/Getty Images, Jalon Daniels. This won't be a close one, at all. ET. Penn State-Iowa isn't the only ranked matchup this week. But MSU has lost its last three games to Washington, Minnesota and Maryland. ET kickoff . The Nittany Lions will play Michigan in the Big House on Oct. 15, followed by a home game against Minnesota and a home game against Ohio State on Oct. 29. Head coach Brian Kelly and the Tigers started the season slow with a loss in Week 1, but it's been mostly positive from there. NC State's best quality is its linebacker room and schemes it runs on the defensive end, but that won't be able to stop Hartman each quarter. ET. And though Tanner McKee has 10 touchdowns against zero interceptions since becoming Stanford's starting quarterback, this will be the toughest defense he has faced by a wide margin. Head coach Jeff Scott, who is in his third season in Tampa, hasn't won more than three games in a season as a head coach. After failing to find the end zone all game, the Dawgs finally scored two touchdowns in the fourth quarter to win 26-22. Both of these teams are trending in opposite directions. UCLA dominated Washington in a Friday night game in Los Angeles to improve to 5-0 and earn a top-25 ranking. Merely a road game against the team leading the nationin total offense. The 2022 College Football Week 6 will feature Tennessee Vs LSU and Texas Tech Vs Oklahoma St. We will have 6 more Premium Picks against the spread this week! ET: Ohio 35, Akron 13, Georgia Southern at Georgia State, 2 p.m. Instead, OSU-Rutgers looked an awful lot like the "very good team against very bad team" matchup we've grown accustomed to watching in recent years. It looks like they'll keep a position there since they're playing a Memphis team that's on a three-game losing streak, had a 1-4 record in October and has fielded one of the worst defenses in the AAC. The Rebels only had one gain of 20 or more yards, and that 42-yard pass to Chase Rogers didn't come until the fourth quarter when the game was effectively over. The Wolfpack improved to 4-1 with a closer-than-most-expected 34-27 home win over Louisiana Tech. The Red River Showdown between No. Two undefeated Big 12 teams will be in the spotlight in Week 6, but just not the two we expected to be talking about. ET. Up until two weeks ago, at least Texas A&M had a great defense. While the sample size is relatively small, Week 6 is unquestionably the biggest week of the 2020 college football season so far. Oklahoma State is still figuring things out on offense, averaging a modest (certainly by head coach Mike Gundy's standards) 25.4 points per game. No. The Lobos have also averaged just 212 yards of total offense and 7.7 points during their current three-game losing streak, so this one should be over by halftime. Maybe things will get a little weird for this night game at Kyle Field, but it seems more likely that 'Bama will run away with what will be its 20th consecutive win. 2020's meeting was a 53-45 shootout that the Sooners won. Odds and lines subject to change. ET (Thursday). With Notre Dame's offense hitting over 40 points in two straight games, the Fighting Irish may have found the key to saving their season. No. 17 TCU . 8 Tennessee for prediction, No. He's now up to 17 total touchdowns on the year. NC State fell 30-20 to Clemson last week, and Florida State suffered its first loss to Wake Forest last week. ET. The Midshipmen have averaged 45.8 points against the Mustangs, and they enter this contest right after a 34-30 win over UCF in which they rushed for 348 yards and three touchdowns. 13 Arkansas (4-1) at No. Instead of dealing with quarterback Garret Shrader and running back Sean Tucker in a top-six run game, opponents gain an advantage when they make Syracuse throw. The Bulldogs lost 31-16 to LSU in Week 3, so this game doesn't have a ton of SEC West implications, with Alabama leading the pack. . There isn't much to worry about since the Tar Heels are playing a Virginia team with quarterback Brennan Armstrong, who's recorded nine interceptions this season. ET, CBS), No. Vanderbilt's defense checks in at 114th in scoring defense nationally. Speaking of the Crimson Tide, Tennessee needs to avoid looking ahead to that game. Let's get back on the right track. ET: USC's season has oscillated back and forth between "Win by at least 23 points" and "get embarrassed on defense in a loss by double digits." The Hoosiers started the season 3-0, including a Week 1 win over Illinois. 7 Ohio State (4-1) vs. Maryland (4-1), Noon ET. Week 10 features the biggest game of the year, with AP No. Maye is tied at No. There aren't many teams that let one player carry their entire offense, but the Fighting Illini ride the success of running back Chase Brown. ET, Georgia State (1-4) at Louisiana-Monroe (2-2), 8 p.m. Even though the Commodores look much stronger under Clark Lea this season, sitting at 3-2, Ole Miss just has too much talent on offense. Each of their games has been extremely tight, and they're two points away from being one of the few undefeated teams standing. And this Arkansas defense has been every bit as stingy as Alabama's thus far this year. ET: Northern Illinois 27, Central Michigan 18, Western Michigan at Bowling Green, 7 p.m. ET: Virginia's Brennan Armstrong is averaging nearly 400 passing yards per game, but Louisville's Malik Cunningham is the quarterback to watch in this one. Week 6 of the college football season features four matchups between teams ranked in the latest AP Top 25. That streak will continue this weekend when Indiana is unable to find any yards on the ground and has trouble scoring. Miami quarterback Tyler Van Dyke entered 2022 with plenty of offseason hype, but he hasn't performed as well as expected early in the year. 6 USC (-11) (7:30 p.m. The 2022 college football season started rocky with upsets and constant changes in the Top 10, but clear candidates for the College Football Playoff have emerged. , should roll on Saturday in scoring defense nationally biggest game of the on! 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