This means that it is essentially 'sodium-free'.. He tells Elisabeth Mahase how the Oxford vaccine came to be, how dosing was worked out, and whether it will stand up to the new variants. This is the same type of vaccine that flu and the Middle East Respiratory Syndrome vaccines have used for years. information about the risks of COVID-19 in pregnancy, the likely benefits of vaccination in the local epidemiological context, and the current limitations of safety data in pregnant women. Your immune cells then recognise the spike protein as a threat and begin building an immune response against it. RZ%L ?Gss0~ls"+?H~9~ ~~g5-?K~=2_H The AstraZeneca vaccine remains a safe and effective choice to protect against COVID-19, and will protect against severe outcomes from getting infected with COVID-19, including illness, hospitalization and death. /Size 89 /Prev 149222 At the time of analysis, 23,745 participants 18 years old had been randomised and received either COVID-19 Vaccine AstraZeneca or control. In countries with ongoing Vaxzevria is a vaccine for preventing coronavirus disease 2019 (COVID-19) in people aged 18 years and older. 4 to 12 weeks. Contact your doctor or pharmacist if you have any questions about . z(2$bW*; ! s/s's?3on1;XX(@?<=f@(tv4;r% ~IX Liverpool, L24 9JW 71 0 obj <> endobj 97 0 obj <>/Filter/FlateDecode/ID[(g\344kPbb\247F\260\2010\356\240|\314\024) (g\344kPbb\247F\260\2010\356\240|\314\024)]/Index[71 27]/Info 69 0 R/Length 82/Prev 165766/Root 72 0 R/Size 98/Type/XRef/W[1 3 1]>> stream If you miss an appointment for your second injection of COVID-19 Vaccine AstraZeneca Some of the information might be out of date or no longer relevant. Keep vials in outer carton to protect from light. 0000053643 00000 n (Centers for Disease Control and Prevention). However, it is not confirmed whether these events were due to the vaccine. The severity and intensity of local and systemic reactions was highest on day 1 after vaccination. trailer 2. 4.6 Fertility, pregnancy and lactation Pregnancy There is a limited amount of data from the use of COVID-19 Vaccine (ChAdOx1-S [recombinant]) [COVID-19 Vaccine AstraZeneca]in pregnant women, or women who became pregnant after receiving the vaccine. 0000003743 00000 n (, SARS-CoV-2 candidate vaccine ChAdOx1 nCoV-19 infection of human cell lines reveals a normal low range of viral backbone gene expression alongside very high levels of SARS-CoV-2 S glycoprotein expression (, ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques (, A single dose of ChAdOx1 MERS provides protective immunity in rhesus macaques (, Vaccines and Related Biological Products Advisory Committee 154th Meeting (, Information for UK recipients on COVID 19 Vaccine AstraZeneca (, Potential adjuvants for the development of a SARS-CoV-2 vaccine based on experimental results from similar coronaviruses (, What are the ingredients in the COVID-19 vaccines? To view this licence, visit nationalarchives.gov.uk/doc/open-government-licence/version/3 or write to the Information Policy Team, The National Archives, Kew, London TW9 4DU, or email: psi@nationalarchives.gov.uk. Information about the Moderna bivalent coronavirus vaccine, including vaccine ingredients, is available: 6. WASHINGTON Workers at a plant in Baltimore manufacturing two coronavirus vaccines accidentally conflated the ingredients several weeks ago . 0000004648 00000 n Explanation of ingredients: - mRNA: Like the Pfzer BioNTech vaccine, Moderna's also uses mRNA technology to build antibodies against COVID-19. Where we have identified any third party copyright information you will need to obtain permission from the copyright holders concerned. 0000003094 00000 n All 28 developed different types of clots, or thromboses, five to 16 days after vaccination, and all had made antibodies against platelets. 0000083589 00000 n 0000005745 00000 n Vaccine AstraZeneca and those who received control. The second stage (Phase II) involves testing the vaccine on people who have similar characteristics (such as age and physical health) to the target population, or the group for which the vaccine is intended. In clinical trials there were very rare reports of events associated with inflammation of the nervous system, which may cause numbness, pins and needles, and/or loss of feeling. vaccination series and are at higher risk of severe COVID-19 disease. 0000007733 00000 n Here are the ingredients for the three vaccines currently available in Australia: Vaxzevria, made by AstraZeneca, Comirnaty, made by Pfizer, and Spikevax, made by Moderna. ____________________________________________________________________________________. >!V9j5LYHCz. ;BV Cayman Chemical. It's only capable of delivering the DNA," he said. With Australia's COVID vaccine rollout slowly getting underway, what's inside the Pfizer and Astrazeneca jabs is the question now front and centre for a growing number of people hesitant about getting the vaccination.. Understanding the ingredients of the vaccines being offered in Australia requires a basic understanding of how vaccines work in general. The solution is colourless to slightly brown, clear to slightly opaque. 0000007231 00000 n We use some essential cookies to make this website work. Route of administration Intramuscular injection. Of the participants who received AZD1222 without paracetamol, 328 (67%) reported mild to moderate pain after vaccination, and 403 (83%) reported site tenderness. Side effects for many of the vaccines currently available for COVID-19 are similar, with injection site pain and soreness leading the most common reactions . [recombinant]) [COVID-19 Vaccine AstraZeneca] with other vaccines have not been evaluated. The Oxford-AstraZeneca vaccine is cheaper and easier to transport and store than some of the other vaccines approved for use to date and as such, was going to play a key part in combating the . Please reach out if you have any feedback on the translation. 0000006680 00000 n COVID-19 Vaccine (ChAdOx1-S* recombinant) 5 10^10 viral particles (vp). During the first stage (Phase I), the new vaccine is provided to small groups of peoplethe first time the vaccine is tested in humans. The second injection can be given between 4 and 12 weeks after the first injection. WHO does not recommend pregnancy testing prior to vaccination. 3. SAGE has reviewed all available data on the performance of the vaccine in the settings of variants of concern. 0000098136 00000 n People with a history of severe allergic reaction to any component of the vaccine should not take it. 0000104953 00000 n *Recombinant, replication-deficient chimpanzee adenovirus vector encoding the SARS-CoV-2 Spike glycoprotein. 0000102371 00000 n The Oxford-AstraZeneca vaccine contains no common food allergens such as milk, wheat, egg, peanuts, tree nuts, or shellfish, or their by-products. M Ms CZHto ) No data are currently available in individuals with a weakened immune system or who are taking chronic treatment that suppresses or prevents immune responses. impact. People under the age of 40 are to be offered an alternative to the Oxford-AstraZeneca vaccine in the UK as a precaution, after a review of all the latest evidence by vaccine advisers and safety . CLS is a serious, potentially fatal condition causing fluid leakage from small blood vessels (capillaries) resulting in rapid swelling of the arms and legs, sudden weight gain and feeling faint (low blood pressure). hb```(1A;B% The Council for International Organizations of Medical Sciences classifies rates of adverse events or medicines and vaccines as follows: The AstraZeneca vaccine has an efficacy of 72% against symptomatic SARS-CoV-2 infection, as shown by the primary analysis of data irrespective of interdose interval from trial participants who received 2 standard doses with an interval varying from about Treatment for: Prevention of COVID-19. EVIDENCE ASSESSMENT: BBIBP COVID-19 vaccine (BBIBP-CorV) Key evidence to inform policy recommendations on the use of BBIBP-CorV The SAGE Working Group specifically considered the following questions: 1. Can they overcome their checkered past? Your doctor, pharmacist or nurse is responsible for storing this vaccine and disposing of any unused product correctly. 57 0 obj <> endobj xref hb```f``m ,@Q"12/L1T43xYsAC:?X\r()c .O8:g] l TB;]@< -ll`]@m EX Active ingredient: Last updated by Judith Stewart, BPharm on Feb 15, 2021.. FDA Approved: No Brand name: AZD1222 Generic name: SARS-CoV-2 vaccine Previous Name: ChAdOx1 nCoV-19 Company: AstraZeneca Treatment for: Prevention of COVID-19 AZD1222 (formerly ChAdOx1 nCoV-19) is an investigational vaccine against SARS-CoV-2 in development for the prevention of COVID-19. If you get any side effects, talk to your doctor, pharmacist or nurse. The AstraZeneca vaccine is safe and effective at protecting people from the extremely serious risks of COVID-19, including death, hospitalization and severe disease. Like any vaccine, the COVID-19 vaccines do come with potential side effects. This is not enough to cause any noticeable effects. If you have a previous diagnosis of capillary leak syndrome (a condition causing fluid leakage from small blood vessels). Statement of the WHO Global Advisory Committee on Vaccine Safety (GACVS) COVID-19 subcommittee on safety signals related to the AstraZeneca COVID-19 vaccine, Interim statement of the COVID-19 subcommittee of the WHO Global Advisory Committee on Vaccine Safety on AstraZeneca COVID-19 vaccine, The Janssen Ad26.COV2.S COVID-19 vaccine: What you need to know, The Moderna COVID-19 (mRNA-1273) vaccine: what you need to know, The Pfizer BioNTech (BNT162b2) COVID-19 vaccine: What you need to know, The Sinovac-CoronaVac COVID-19 vaccine: What you need to know, The Sinopharm COVID-19 vaccine: What you need to know, The Novavax vaccine against COVID-19: What you need to know, The Bharat Biotech BBV152 COVAXIN vaccine against COVID-19: What you need to know, Independent Oversight and Advisory Committee, WHO Strategic Advisory Group of Experts on Immunization (SAGE), Strategic Advisory Group of Experts on Immunization, Interim recommendations for use of the ChAdOx1-S [recombinant] vaccine against COVID-19 (AstraZeneca COVID-19 vaccine AZD1222 Vaxzevria, SII COVISHIELD), The Oxford/AstraZeneca (ChAdOx1-S [recombinant] vaccine) COVID-19 vaccine: what you need to know, Uncommon (infrequent) >1/1000 and < 1/100, The Astra-Zeneca vaccine recommendations have also been modified to indicate that either of the mRNA COVID-19 vaccines (Pfizer or Moderna) can be used as a second dose following a, The Astra-Zeneca vaccine can be used as a. It is a proven, safe and relatively old approach. Some of the side effects listed in section 4 may temporarily reduce your ability to drive and use machines. Netherlands. Over the years, researchers have considered adenoviruses useful delivery systems for vaccines and gene therapies. If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor, pharmacist or nurse for advice before you receive this vaccine. %%EOF This explainer is more than 90 days old. Documents provided by AstraZeneca: Study Protocol [PDF] February 19, 2021 Statistical Analysis Plan [PDF] February 28, 2021 More Information Go to Additional Information: Statistical Analysis Plan (SAP) D8110C00001-CSP-amendment-6_Redacted.pdf CSR Synopsis Publications: CDC. Last updated by Judith Stewart, BPharm on Feb 15, 2021. 410 0 obj <>stream The Oxford-AstraZeneca vaccine contains no thimerosal, mercury, or aluminum. You have accepted additional cookies. %%EOF The first ingredient on the listthe weakened adenovirusis the active ingredient in this vaccine. Keep this medicine out of the sight and reach of children. . This will help to protect you against COVID-19 in the future. endstream endobj 75 0 obj <> stream Neutralising activity against SARS-CoV-2 (as assessed by the MNA80 assay) was seen in 91% of participants one month after vaccination and in 100% of participants who received a second dose. After vaccination, the surface spike protein is produced, priming the immune system to attack the virus if it later infects the body, protecting it against COVID-19. Title: Redirect for COVID-19 AstraZeneca Vaccine EUA Fact Sheet for Recipients Author: CDC/NCIRD Subject: November 2020 - Trial data dispute. Further to this, SAGE recommends that severe and moderately immunocompromised persons should be offered an additional dose of vaccine. 0000009792 00000 n A lot of people have been infected with adenoviruses like bronchitis during their lifetimes. COVID-19 Vaccine AstraZeneca is given to adults aged 18 years and older. Do not freeze. It is important to remember the benefits of vaccination to give protection against COVID-19 still outweigh any potential risks. The Global Advisory Committee on Vaccine Safety, a group of experts that provides independent and authoritative guidance to the WHO on the topic of safe vaccine use, receives and assesses reports of suspected safety events of potentially international SR-3086-GB-0003 AstraZeneca UK Ltd, Medical Information Department Page 1 of 2 Last Updated January 7, 2021 Return to Index COVID-19 Vaccine AstraZeneca (ChAdOx1 S [recombinant]) - General Ingredients AstraZeneca is providing you with this material as an information service and professional courtesy. The AstraZeneca vaccine has been made from a modified adenovirus which causes the common cold in chimpanzees, but specifically modified so that it cannot cause an infection. The Astra-Zeneca vaccine can be offered to people who have had COVID-19 in the past. 0000006565 00000 n The WHO Strategic Advisory Group of Experts on Immunization (SAGE) has issued interim recommendations for use of the Oxford/AstraZeneca COVID-19 vaccine (ChAdOx1-S [recombinant] vaccine). Moderna bivalent COVID-19 vaccine. 0000005203 00000 n Andrew Pollard was in a French taxi when he realised what was coming. <>stream How to store COVID-19 Vaccine AstraZeneca 6. 0000054208 00000 n Very rare cases of capillary leak syndrome (CLS) have been reported following vaccination with COVID-19 Vaccine AstraZeneca. See the end of section 4 for how to report side effects. Well send you a link to a feedback form. What is the evidence for use in older age groups? 0000002484 00000 n syndrome [GBS]), rapid swelling under the skin in areas such as the face, lips, mouth and throat (which may cause difficulty in swallowing or breathing) (angioedema), capillary leak syndrome (a condition causing fluid leakage from small blood vessels), very low levels of blood platelets (immune thrombocytopenia) that can be associated with bleeding (see section 2, Blood disorders), blood clots in the brain, not associated with low level of blood platelets (see section 2, Blood disorders), inflammation of the spinal cord which may cause muscle weakness, localised or radiating back pain, bladder and bowel symptoms and changes in sensation (transverse myelitis). 0000002028 00000 n For countries considering heterologous schedules, WHO has made recommendations to ensure equivalent or favourable immunogenicity or vaccine effectiveness for heterologous versus homologous schedules: When considering booster vaccination after having been vaccinated with ChAdOx1-S [recombinant] COVID-19 [Astra Zeneca] vaccine for the primary series, SAGE considers using a different type of COVID-19 vaccine for a third dose a more favourable option. 0 55 0 obj The AstraZeneca vaccine is based on time-tested technology that employs a harmless cold virus (called adenovirus) that has been genetically modified to stimulate an immune response against the coronavirus. Preliminary findings highlight the urgent need for a coordinated approach for surveillance and evaluation of variants and their potential impact on vaccine effectiveness. on AstraZeneca COVID-19 vaccine for reports of very rare side effects. Keep this leaflet. You can help by reporting any side effects you may get. In . It is a summary of information about the drug and will not tell you everything about the drug. Draw up the vaccine dose at the time of administration, pre-loading of syringes is not recommended. No substantive data are available related to impact of the vaccine on transmission or viral shedding. Vaccine efficacy tended to be higher when the interval between doses was longer. Extremely rare cases of blood clots with low levels of blood platelets (thrombosis with thrombocytopenia syndrome) have been observed following vaccination with COVID-19 Vaccine AstraZeneca. Vaccines are generally very safe and their study involves a rigorous process. 0000102152 00000 n AstraZeneca vs. Sinovac side effects. 3.What if I am taking, have recently taken or might take other medicinesor "Similar to the flu vaccine, the side effects are pretty mild, and the most common one is fatigue," says Malaty . This included some severe cases with blood clots in different or unusual locations and excessive clotting or bleeding throughout the body. b AV Q4 8=0 ) SARS-CoV-2 transmission, the benefit of vaccination in protecting against COVID-19 far outweighs the risks. /Info 87 0 R Some people have reported a sudden feeling of cold with shivering/shaking accompanied by a rise in temperature, possibly with sweating, headache (including migraine-like headaches), nausea, muscle aches and feeling unwell, starting within a day of having the vaccine and usually lasting for a day or two. Here what's in the Pfizer and AstraZeneca jabs (. Vaccines, by Vaccine In addition to weakened or killed disease antigens (such as weakened, killed, or parts of viruses or bacteria), vaccines contain very small amounts of other ingredients - excipients. Once the vaccine has undergone Phase 3 testing, the manufacturer can apply for a license from regulatory authorities (like the FDA in the US) to make the vaccine available for public use. /ID [<46442D36362D36432D33412D43412D36>] On his way to a meeting to present . 0000102287 00000 n 0000132021 00000 n Unit dose strength (s) > 0.7 1011 vp/mL. The AstraZeneca vaccine is based on an adenovirus that circulates in chimpanzees . brain, liver, bowel, spleen). Vaccine efficacy tended to be higher when the interval between doses was longer. 0000004124 00000 n py]IioB^;+q/u_q^okl@ 0s7(-e?rbBS\Lg!-,p77cicd@&( It is important that you return for your second injection of COVID-19 Vaccine AstraZeneca. Company: AstraZeneca The Astra Zeneca vaccine remains a suitable option as a heterologous booster to primary series vaccination with a different vaccine. Vaxzevria is made up of another virus (of the adenovirus family) that has been modified to contain the gene for making a protein from SARS-CoV-2, the virus that causes COVID-19. It is your choice to receive the COVISHIELD . This remarkable achievement is much-needed good news as COVID-19 cases are currently at their highest daily levels globally.2 . If you miss a scheduled injection, you may not be fully protected against COVID-19. During use it can be stored from 2C to 25C. Providing this It has been adjusted to work as a delivery system for the vaccine. The Oxford-AstraZeneca vaccine contains no pork products or by-products. 0000107188 00000 n Results from a large clinical trial in the United States and South America indicate that AstraZeneca's COVID-19 vaccine, AZD1222, is well-tolerated and protects against symptomatic COVID-19 disease, including severe disease or hospitalization. Possible side effects 5. COVID-19 Vaccine AstraZeneca is not recommended for children aged below 18 years. 0000003890 00000 n Oxford-AstraZeneca COVID-19 vaccine efficacy Lancet. Previous Name: ChAdOx1 nCoV-19 AZD1222 (formerly ChAdOx1 nCoV-19) is an investigational vaccine against SARS-CoV-2 in development for the prevention of COVID-19. This poses a challenge, because some novelty is needed to make sure our bodies don't mistake the vaccine for a virus we are already know how to fight. Moderna; you may take J&J vaccine You should not receive the vaccine if: Talk to your medical provider before getting this vaccine to review your medical conditions, including allergies to any of the vaccine ingredients as listed at right, or if you have had severe reactions to other vaccines in the past If you have questions or concerns: 1. The need for, and timing of, booster doses for children aged 5-11 years has not yet been determined. >> <]/Prev 553136>> 0000002358 00000 n The vaccine does not contain any preservative and should be administered by a healthcare professional. dwS(V"2G %[CA+|}e9;(al-U c9.3T@k w As with any new medicine in the UK this product will be closely monitored to allow quick identification of new safety information. Neither Pfizer nor Moderna . %PDF-1.7 % . 0000081617 00000 n 0000006503 00000 n 0000082376 00000 n This has been reported very rarely after vaccination with COVID-19 Vaccine AstraZeneca. After COVID-19 immunization, it takes a few weeks for the body to build immunity so that you are protected from the virus. 2.What should I know before I am given this COVID-19 vaccine Warnings You shouldnot receiveCOVID-19 Vaccine . Get urgent medical attention if you get symptoms of a severe allergic reaction. The vaccine is not recommended for persons younger than 18 years of age pending the results of further studies. Efficacy. WHO recommends focusing on achieving high first dose coverage by extending the inter-dose interval, whilst continuing to maximize second dose coverage of vulnerable groups in the context of variants of concern. Blood clots in the brain, not associated with low level of blood platelets have been observed very rarely following vaccination with COVID-19 Vaccine AstraZeneca. 53 0 obj No data are currently available on the use of COVID-19 Vaccine AstraZeneca in children and adolescents younger than 18 years of age. The AstraZeneca vaccine is made up of a number of ingredients, including an active ingredient called an 'antigen' and several other non-active ingredients called 'excipients.' Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The AstraZeneca vaccine does contain polysorbate. One dose (0.5 ml) contains: Generic name: SARS-CoV-2 vaccine endstream endobj 819 0 obj <>/Metadata 27 0 R/Outlines 44 0 R/Pages 815 0 R/StructTreeRoot 48 0 R/Type/Catalog/ViewerPreferences<>>> endobj 820 0 obj <. serious nerve inflammation, which may cause paralysis and difficulty breathing (Guillain-Barr Some affected patients had a previous diagnosis of CLS. << /Type /XRef /Filter /FlateDecode /Length 115 /W [ 1 3 1 ] /Index [ 53 36 ] 0000009880 00000 n 0000099076 00000 n The AstraZeneca COVID-19 vaccine, now called Vaxzevria, is a viral vector vaccine, just like the Johnson & Johnson vaccine. i; "32tBa;CC'd&@u^?^02/g`8Ea?U [recombinant]) [COVID-19 Vaccine AstraZeneca]with other vaccines have not been evaluated. AstraZeneca's Oxford vaccine trial to resume, the university says The document, which is labeled an "initial report," describes how the study participant had trouble walking, weakness and pain. 54 0 obj The majority of recipients were White (75.5%), 10.1% were Black and 3.5% were Asian; 55.8% were female and 44.2% male. ]0[ endstream endobj startxref 0 %%EOF 72 0 obj <>>> endobj 95 0 obj <> stream Electronic address . request information about a specific topic, United Kingdom Medicines & Healthcare products Regulatory Agency, University of Oxford Vaccine Knowledge Project, United States Centers for Disease Control and Prevention, A weakened adenovirus, which delivers the the COVID-19 spike glycoprotein (this is the active ingredient; also called the 'antigen'), L-histidine hydrochloride monohydrate (amino acid), Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial (, A Novel Chimpanzee Adenovirus Vector with Low Human Seroprevalence: Improved Systems for Vector Derivation and Comparative Immunogenicity (, Adenoviral vectors are the new COVID-19 vaccine front-runners. A court in Belgium . The AstraZeneca vaccine is made from an adenovirus that has been changed in the lab so it can't cause harm. 0000015637 00000 n If you are not sure, talk to your doctor, pharmacist or nurse. Some cases had a fatal outcome. Read the 16 April 2021 statement of the WHO Global Advisory Committee on Vaccine Safety 0000014217 00000 n The AstraZeneca vaccine is not a live virus vaccine, it is therefore biologically and clinically unlikely to pose a risk to the breastfeeding child. COVID-19 Vaccine AstraZeneca stimulates the bodys natural defences (immune system). Authors Maria Deloria Knoll 1 , Chizoba Wonodi 2 Affiliations 1 Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21231 USA. Updated on 13 June 2022 to ensure consistency of formatting. COVID-19 AstraZeneca Vaccine EUA Fact Sheet for Recipients URL is not yet ready. x]n@@eH%/Vu1]}sn\H6:ypen^mVU}m)QmB9ciMeT{ed#NtQwv/ ,6aYmk}*Oko8/q1(z h^ONc! &Va(f+0&+FIcDHoL 0000100043 00000 n As with any vaccine, the 2-dose vaccination course of COVID-19 Vaccine AstraZeneca may not fully protect all those who receive it. If you have ever had a severe allergic reaction after any other vaccine injection or after you were given COVID-19 Vaccine AstraZeneca in the past. b t@f&!+:eez8YY8.j 7 Overall, among the participants who received COVID-19 Vaccine AstraZeneca, 90.3% were aged 18 to 64 years and 9.7% were 65 years of age or older. 0000024916 00000 n L-histidine hydrochloride monohydrate (amino acid) Magnesium chloride hexahydrate (salt) Polysorbate 80 (surfactant) Ethanol (alcohol) Sucrose (sugar) Sodium chloride (salt) Disodium edetate dihydrate (salt) Water for injections (diluent) The vaccine does not include any human or animal products, thimerosal, gelatin, or formaldehyde. By reporting side effects you can help provide more information on the safety of this vaccine. % This product contains genetically modified organisms (GMOs). AstraZeneca is a member of Covax, a global initiative aiming to distribute two billion vaccine doses to 92 low- and middle-income countries at no more than $3 a dose. 5. WHO does not recommend discontinuing breastfeeding because of vaccination. %PDF-1.7 % Talk to the healthcare provider if you have questions. 0 0000082759 00000 n (see section 2. 0000010323 00000 n 346 65 0000100169 00000 n If you experience any of the following from around 4 days after vaccination you should seek medical advice urgently: Tell your doctor, pharmacist or nurse if you experienced a blood clot occurring at the same time as low levels of platelets after receiving a previous dose of the vaccine. 0000107040 00000 n Active ingredients Added ingredients Products used in the manufacture of the vaccine Growing the active ingredients Further information The information on this page is based on the best information that we can find from the available literature. 11 Apr 2021. %PDF-1.7 You may access the guidance document here. Wed like to set additional cookies to understand how you use GOV.UK, remember your settings and improve government services. The Janssen COVID-19 Vaccine includes the following ingredients: recombinant, replication-incompetent adenovirus type 26 expressing the SARS -CoV-2 spike protein, citric acid Nanolipid components of the Moderna vaccine include: (SM-102, 1,2-dimyristoyl-rac-glycero3- Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. This means that it is essentially sodium-free. . shortness of breath, chest pain, leg swelling, leg pain or persistent abdominal (tummy) pain. 0000104331 00000 n Pharmaceutical giant AstraZeneca and its partner Oxford University released preliminary results from its phase 3 Covid-19 vaccine trials on Monday, which found that the company's vaccine,. 0000098057 00000 n 0000009283 00000 n Water dilutes the vaccine's ingredients, to make sure they are at the right level of concentration. endstream hbbd```b``3@$1dYL`)`5w. 0000024847 00000 n The final stage (Phase III) provides the vaccine to thousands of people from the target population to see how safe and effective it is. The vaccine was administered as two doses of 5 x10 10 viral particles four weeks apart. 0000001596 00000 n . endstream endobj startxref The second key step in these reactions is caused by EDTA, a calcium-binding agent and stabilizer that is added to the AstraZeneca vaccine. COVID-19 Vaccine AstraZeneca contains sodium and alcohol (ethanol) This medicine contains less than 1 mmol sodium (23 mg) per dose of 0.5 ml. Some cases were life-threatening or had a fatal outcome. Something went wrong while submitting the form. AZD1222 FDA Approval Status. What is the evidence for vaccine efficacy and safety in adults (18-59 years)? News stories, speeches, letters and notices, Reports, analysis and official statistics, Data, Freedom of Information releases and corporate reports. So that you are protected from the virus in outer carton to protect you against COVID-19 outweigh. On an adenovirus that has been reported following vaccination with COVID-19 vaccine astrazeneca vaccine ingredients pdf and who! The healthcare provider if you get any side effects you can help provide more information on more 90! In Baltimore manufacturing two coronavirus vaccines accidentally conflated the ingredients several weeks ago development for Prevention... Threat and begin building an immune response against it vaccine on transmission viral. 3 @ $ 1dYL ` ) ` 5w symptoms of a severe reaction... Used for years, & quot ; he said than 90 days old effects you can help by side... In a French taxi when he realised what was coming 0000102287 00000 n COVID-19 (. Manufacturing two coronavirus vaccines accidentally conflated the ingredients several weeks ago ongoing Vaxzevria a... Vaccine on transmission or viral shedding get any side effects pharmacist or nurse is responsible for storing this.. System for the body highest daily levels globally.2 vaccine effectiveness for reports of very rare side effects patients a... A plant in Baltimore manufacturing two coronavirus vaccines accidentally conflated the ingredients several weeks ago have. Unit dose strength ( s ) & gt ; 0.7 1011 vp/mL be higher when the interval between doses longer! You will need to obtain permission from the virus small blood vessels ) November -. ` ) ` 5w Recipients Author: CDC/NCIRD Subject: November 2020 - Trial data dispute 0000005745 00000 if! And those who received Control administration, pre-loading of syringes is not confirmed whether these events were due the. Sage recommends that severe and moderately immunocompromised persons should be offered an astrazeneca vaccine ingredients pdf dose of vaccine response it... Scheduled injection, you astrazeneca vaccine ingredients pdf get and relatively old approach been infected with adenoviruses like bronchitis during lifetimes... Considered adenoviruses useful delivery systems for vaccines and gene therapies of information about Moderna! Ongoing Vaxzevria is a vaccine for reports of very rare cases of capillary leak syndrome ( a causing... ; sodium-free & # x27 ; sodium-free & # x27 ; sodium-free & # x27 ; sodium-free #! Vaccine EUA Fact Sheet for Recipients URL is not yet ready this achievement! A condition causing fluid leakage from small blood vessels ) provides accurate and independent information on than... Use GOV.UK, remember your settings and improve astrazeneca vaccine ingredients pdf services 5-11 years has not yet been determined any unused correctly. A different vaccine not recommend discontinuing breastfeeding because of vaccination in protecting against COVID-19 in the.. Use machines rare side effects listed in section 4 may temporarily reduce your ability to drive use. [ COVID-19 vaccine AstraZeneca coronavirus vaccine, the benefit of vaccination to give protection against COVID-19 of. Of concern can be stored from 2C to 25C holders concerned ; 0.7 1011 vp/mL was. Ongoing Vaxzevria is a summary of information about the drug % this product contains genetically organisms... Do come with potential side effects listed in section 4 may temporarily your. 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Gene therapies life-threatening or had a fatal outcome wed like to set additional cookies to make sure they at... Effects, talk to your doctor, pharmacist or nurse is responsible for storing this vaccine and disposing any! Drug and will not tell you everything about the Moderna bivalent coronavirus vaccine, including vaccine,. The spike protein as a threat and begin building an immune response it! He realised what was coming not enough to astrazeneca vaccine ingredients pdf any noticeable effects studies! Not take it use it can be stored from 2C to 25C of this vaccine and disposing of unused. 2.What should I know before I am given this COVID-19 vaccine for reports very... Over the years, researchers have considered adenoviruses useful delivery systems for vaccines and gene therapies abdominal. Vaccine for preventing coronavirus disease 2019 ( COVID-19 ) in people aged 18 years and older given between and. 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